At least three people are dead after a UPS aircraft crashed upon departing the Louisville Muhammad Ali International Airport in Kentucky, officials said Tuesday, sending a massive plume of smoke into the air and leading authorities to urge residents of a large swath of the nearby area to shelter in place following the fiery crash.

Kentucky Gov. Andy Beshear said he believes the number of fatalities will increase following the “catastrophic” crash.

At least 11 people were injured, some with “very significant” injuries,” he said.

Three crew members were on board the plane, according to UPS, which said it has not confirmed any injuries.
A shelter-in-place was initially issued within 5 miles of the airport but was subsequently expanded to all areas north of the airport to the Ohio River, police said. Areas south of the Outer Loop have since been cleared from the shelter-in-place, police said.

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